February 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Spondylolisthesis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Spondylolisthesis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Spondylolisthesis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Spondylolisthesis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.

1:Risk Factors of Postoperative Low Back Pain for Low-Grade Degenerative Spondylolisthesis: An At Least 2-Year Follow-Up Retrospective Study.
Authors:Guan F, Bao R, Zhu L, Guan G, Chi Z, Gu J, Yu Z
Institution:1st Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China; Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut, USA. Heilongjiang Province, China. Province, China. Province, China. Province, China. Province, China; Department of Neurological Surgery, Weill Cornell University, New York, New York, USA. Electronic address: jiaaogu@outlook.com. Province, China. Electronic address: haerbinmed@aliyun.com.
Journal:World Neurosurg. 2017 Nov;107:789-794. doi: 10.1016/j.wneu.2017.08.109. Epub 2017 Aug 24.

2:Which Approach Is Advantageous to Preventing Development of Adjacent Segment Disease? Comparative Analysis of 3 Different Lumbar Interbody Fusion Techniques (ALIF, LLIF, and PLIF) in L4-5 Spondylolisthesis.
Authors:Lee CW, Yoon KJ, Ha SS
Institution:Department of Neurosurgery, St. Peter's Hospital, Seoul, Korea. Electronic address: mannitol240@gmail.com.
Journal:World Neurosurg. 2017 Sep;105:612-622. doi: 10.1016/j.wneu.2017.06.005. Epub 2017 Jun 8.

3:Outcomes of Posterolateral Fusion with and without Instrumentation and of Interbody Fusion for Isthmic Spondylolisthesis: A Prospective Study.
Authors:Endler P, Ekman P, Moller H, Gerdhem P
Institution:1Department of Clinical Science, Intervention and Technology, Karolinska Institutet, and Department of Orthopaedics, Karolinska University Hospital, Stockholm, Sweden 2Department of Clinical Sciences, Karolinska Institutet, Sodersjukhuset, and Department of Orthopaedics, Sodersjukhuset, Stockholm, Sweden.
Journal:J Bone Joint Surg Am. 2017 May 3;99(9):743-752. doi: 10.2106/JBJS.16.00679.

4:The Outcomes of Minimally Invasive versus Open Posterior Approach Spinal Fusion in Treatment of Lumbar Spondylolisthesis: The Current Evidence from Prospective Comparative Studies.
Authors:Wu AM, Chen CH, Shen ZH, Feng ZH, Weng WQ, Li SM, Chi YL, Yin LH, Ni WF
Institution:Department of Orthopedics, Second Affiliated Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Zhejiang Spine Center, Wenzhou, Zhejiang, China.; Department of Orthopedics, Hainan Medical College, Haikou, Hainan, China.; Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Journal:Biomed Res Int. 2017;2017:8423638. doi: 10.1155/2017/8423638. Epub 2017 Jan 5.

5:Posterior lumbar interbody fusion with cortical bone trajectory screw fixation versus posterior lumbar interbody fusion using traditional pedicle screw fixation for degenerative lumbar spondylolisthesis: a comparative study.
Authors:Sakaura H, Miwa T, Yamashita T, Kuroda Y, Ohwada T
Institution:Department of Orthopaedic Surgery, Kansai Rosai Hospital, Amagasaki, Hyogo; and.
Journal:J Neurosurg Spine. 2016 Nov;25(5):591-595. doi: 10.3171/2016.3.SPINE151525. Epub 2016 May 27.

6:Lumbar Degenerative Spondylolisthesis: Changes in Surgical Indications and Comparison of Instrumented Fusion With Two Surgical Decompression Procedures.
Authors:Inui T, Murakami M, Nagao N, Miyazaki K, Matsuda K, Tominaga Y, Kitano M, Hasegawa H, Tominaga S
Institution:Department of Neurosurgery, Tominaga Hospital, Naniwa-ku, Osaka-shi, Osaka, Japan.
Journal:Spine (Phila Pa 1976). 2017 Jan 1;42(1):E15-E24. doi: 10.1097/BRS.0000000000001688.

7:Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis.
Authors:Ghogawala Z, Dziura J, Butler WE, Dai F, Terrin N, Magge SN, Coumans JV, Harrington JF, Amin-Hanjani S, Schwartz JS, Sonntag VK, Barker FG 2nd, Benzel EC
Institution:From the Alan L. and Jacqueline B. Stuart Spine Research Center, the Department of Neurosurgery, Lahey Hospital and Medical Center, Burlington (Z.G., S.N.M.), and the Department of Neurosurgery, Massachusetts General Hospital (W.E.B., J.-V.C.E.C., F.G.B.), and Tufts Clinical and Translational Science Institute, Tufts University School of Medicine (N.T.), Boston - all in Massachusetts; Wallace Trials Center, Greenwich Hospital, Greenwich (Z.G.), and Yale Center for Analytical Sciences, Yale School of Public Health, New Haven (J.D., F.D.) - both in Connecticut; the Department of Neurosurgery, University of New Mexico, Albuquerque (J.F.H.); the Department of Neurosurgery, University of Illinois at Chicago, Chicago (S.A.-H.); Perelman School of Medicine (J.S.S.), Wharton School of Business (J.S.S), and the Leonard Davis Institute (J.S.S.), University of Pennsylvania, Philadelphia; Barrow Neurosurgical Associates, Barrow Neurological Institute, Phoenix, AZ (V.K.H.S.); and the Center for Spine Health and the Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland (E.C.B.).
Journal:N Engl J Med. 2016 Apr 14;374(15):1424-34. doi: 10.1056/NEJMoa1508788.

8:Anterior lumbar inter-body fusion with instrumentation compared with posterolateral fusion for low grade isthmic-spondylolisthesis.
Authors:Chandra V, Singh RK
Journal:Acta Orthop Belg. 2016 Mar;82(1):23-30.

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