December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Spondylolisthesis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Spondylolisthesis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Spondylolisthesis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Spondylolisthesis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.

1:Outcomes of Posterolateral Fusion with and without Instrumentation and of Interbody Fusion for Isthmic Spondylolisthesis: A Prospective Study.
Authors:Endler P, Ekman P, Moller H, Gerdhem P
Institution:1Department of Clinical Science, Intervention and Technology, Karolinska Institutet, and Department of Orthopaedics, Karolinska University Hospital, Stockholm, Sweden 2Department of Clinical Sciences, Karolinska Institutet, Sodersjukhuset, and Department of Orthopaedics, Sodersjukhuset, Stockholm, Sweden.
Journal:J Bone Joint Surg Am. 2017 May 3;99(9):743-752. doi: 10.2106/JBJS.16.00679.

2:Microsurgical Posterolateral Foraminotomy on Patients with Adult Isthmic Spondylolisthesis.
Authors:Chang HS
Institution:Department of Neurosurgery, Saitama Medical Center, Saitama Medical University, Kamoda, Kawagoe, Saitama, Japan. Electronic address: chang-ind@umin.ac.jp.
Journal:World Neurosurg. 2017 Apr;100:434-439. doi: 10.1016/j.wneu.2017.01.040. Epub 2017 Jan 19.

3:One-Level Lumbar Degenerative Spondylolisthesis and Posterior Approach: Is Transforaminal Lateral Interbody Fusion Mandatory?: A Randomized Controlled Trial With 2-Year Follow-Up.
Authors:Challier V, Boissiere L, Obeid I, Vital JM, Castelain JE, Benard A, Ong N, Ghailane S, Pointillart V, Mazas S, Mariey R, Gille O
Institution:*Spine Unit 1, Bordeaux University Hospital, Gironde, France daggerClinical Epidemiology Unit, Bordeaux University Hospital, Gironde, France.
Journal:Spine (Phila Pa 1976). 2017 Apr 15;42(8):531-539. doi: 10.1097/BRS.0000000000001857.

4:Modeled cost-effectiveness of transforaminal lumbar interbody fusion compared with posterolateral fusion for spondylolisthesis using N(2)QOD data.
Authors:Carreon LY, Glassman SD, Ghogawala Z, Mummaneni PV, McGirt MJ, Asher AL
Institution:Norton Leatherman Spine Center, Louisville, Kentucky; Hospital and Medical Center, Burlington, Massachusetts; California; and.
Journal:J Neurosurg Spine. 2016 Jun;24(6):916-21. doi: 10.3171/2015.10.SPINE15917. Epub 2016 Feb 19.

5:Patient-Based Surgical Outcomes of Posterior Lumbar Interbody Fusion: Patient Satisfaction Analysis.
Authors:Okuda S, Fujimori T, Oda T, Yamasaki R, Maeno T, Yamashita T, Matsumoto T, Iwasaki M
Institution:*Department of Orthopaedic Surgery, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Kita-ku, Sakai, Osaka, JapandaggerDepartment of Orthopaedic Surgery, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka, Japan.
Journal:Spine (Phila Pa 1976). 2016 Feb;41(3):E148-54. doi: 10.1097/BRS.0000000000001188.

6:Distraction Laminoplasty With Interlaminar Lumbar Instrumented Fusion (ILIF) for Lumbar Stenosis With or Without Grade 1 Spondylolisthesis: Technique and 2-Year Outcomes.
Authors:Cuellar JM, Field JS, Bae HW
Institution:*The Spine Center, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA daggerDesert Institute for Spine Care (DISC), Phoeniz, AZ.
Journal:Spine (Phila Pa 1976). 2016 Apr;41 Suppl 8:S97-S105. doi: 10.1097/BRS.0000000000001484.

7:Dynamic stabilization for L4-5 spondylolisthesis: comparison with minimally invasive transforaminal lumbar interbody fusion with more than 2 years of follow-up.
Authors:Kuo CH, Chang PY, Wu JC, Chang HK, Fay LY, Tu TH, Cheng H, Huang WC
Institution:Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital; Hospital; Hospital; Hospital; Hospital; Hospital; Sinica, Taipei, Taiwan. Hospital; Hospital;
Journal:Neurosurg Focus. 2016 Jan;40(1):E3. doi: 10.3171/2015.10.FOCUS15441.

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